Shiva Das, PhD

Department:
Radiation Oncology

Division:
Radiation Physics

Physical Address:
Box 3295
DUMC
Durham, NC 27710

Appointment Telephone:
9196815424

Research Interests:
Intensity Modulated Radiotherapy optimization. Functional Image-guided radiotherapy (PET, SPECT). Modeling of Radiation-induced normal tissue complications (lung, cardiac) using neural nets, MART, self organizing maps, etc. Optimal selection of beam orientations for radiotherapy. Hyperthermia modeling.

Current Funded Grants:
NCI P01 CA042745-19: Hyperthermia and Perfusion Effects in Cancer Therapy,Project 2: Real Time Modeling and Control Using Finite Elements and MRI (Program Director).
NCI 1R01 CA115748-01A1: Accurate Prediction of Cardiac and Lung Radiation Injury (Principal Investigator).
Varian Medical Systems: Incorporation of Functional Image-guidance in Radiotherapy Planning (Principal Investigator).

Graduate School Teaching:
MP322: Advanced Photon Beam Radiation Therapy Planning (Fall Semester)

Postdoctoral Research Associates (Past and Current):
Alan Baydush, Ph.D.
Shifeng Chen, Ph.D.
Kung-Shan Cheng, Ph.D.
Sarah McGuire, Ph.D.
Vadim Stakhursky, Ph.D.

Publications:
2006 -- Pubmed # 16564444 -- Yin FF, Das S, Kirkpatrick J, Oldham M, Wang Z, Zhou SM. Physics and imaging for targeting of oligometastases. Semin Radiat Oncol. 2006 Apr;16(2):85-101.

2005 -- Pubmed # 15719950 -- Das SK, Baydush AH, Zhou S, Miften M, Yu X, Craciunescu O, Oldham M, Light K, Wong T, Blazing M, Borges-Neto S, Dewhirst MW, Marks LB. Predicting radiotherapy-induced cardiac perfusion defects. Med Phys. 2005 Jan;32(1):19-27.

2005 -- Pubmed # 16278169 -- Das SK, Macfall J, McCauley R, Craciunescu O, Dewhirst MW, Samulski TV. Improved magnetic resonance thermal imaging by combining proton resonance frequency shift (PRFS) and apparent diffusion coefficient (ADC) data. Int J Hyperthermia. 2005 Nov;21(7):657-67.

2004 -- Pubmed # 15377100 -- Baydush AH, Marks LB, Das SK. Penalized likelihood fluence optimization with evolutionary components for intensity modulated radiation therapy treatment planning. Med Phys. 2004 Aug;31(8):2335-43.

2004 -- Pubmed # 15145182 -- Das SK, Bell M, Marks LB, Rosenman JG. A preliminary study of the role of modulated electron beams in intensity modulated radiotherapy, using automated beam orientation and modality selection. Int J Radiat Oncol Biol Phys. 2004 Jun 1;59(2):602-17.

2004 -- Pubmed # 15259648 -- Das SK, Miften MM, Zhou S, Bell M, Munley MT, Whiddon CS, Craciunescu O, Baydush AH, Wong T, Rosenman JG, Dewhirst MW, Marks LB. Feasibility of optimizing the dose distribution in lung tumors using fluorine-18-fluorodeoxyglucose positron emission tomography and single photon emission computed tomography guided dose prescriptions. Med Phys. 2004 Jun;31(6):1452-61.

2004 -- Pubmed # 15738916 -- Miften MM, Das SK, Su M, Marks LB. A dose-volume-based tool for evaluating and ranking IMRT treatment plans. J Appl Clin Med Phys. 2004;5(4):1-14.

2004 -- Pubmed # 15152926 -- Miften MM, Das SK, Su M, Marks LB. Incorporation of functional imaging data in the evaluation of dose distributions using the generalized concept of equivalent uniform dose. Phys Med Biol. 2004 May 7;49(9):1711-21.

2004 -- Pubmed # 15487743 -- Zhou SM, Das S, Wang Z, Marks LB. Relationship between the generalized equivalent uniform dose formulation and the Poisson statistics-based tumor control probability model. Med Phys. 2004 Sep;31(9):2606-9.

2003 -- Pubmed # 12504056 -- Das S, Cullip T, Tracton G, Chang S, Marks L, Anscher M, Rosenman J. Beam orientation selection for intensity-modulated radiation therapy based on target equivalent uniform dose maximization. Int J Radiat Oncol Biol Phys. 2003 Jan 1;55(1):215-24.

2002 -- Pubmed # 12512724 -- Miften MM, Das SK, Shafman TD, Marks LB. Optimization of a 90Sr/90Y radiation source train stepping for intravascular brachytherapy. Med Phys. 2002 Dec;29(12):2891-6.

2001 -- Pubmed # 11347728 -- Craciunescu OI, Das SK, McCauley RL, MacFall JR, Samulski TV. 3D numerical reconstruction of the hyperthermia induced temperature distribution in human sarcomas using DE-MRI measured tissue perfusion: validation against non-invasive MR temperature measurements. Int J Hyperthermia. 2001 May-Jun;17(3):221-39.

2001 -- Pubmed # 11322534 -- Craciunescu OI, Das SK, Poulson JM, Samulski TV. Three-dimensional tumor perfusion reconstruction using fractal interpolation functions. IEEE Trans Biomed Eng. 2001 Apr;48(4):462-73.

2001 -- Pubmed # 11764035 -- Craciunescu OI, Raaymakers BW, Kotte AN, Das SK, Samulski TV, Lagendijk JJ. Discretizing large traceable vessels and using DE-MRI perfusion maps yields numerical temperature contours that match the MR noninvasive measurements. Med Phys. 2001 Nov;28(11):2289-96.

2001 -- Pubmed # 11719964 -- Das SK, Jones EA, Samulski TV. A method of MRI-based thermal modelling for a RF phased array. Int J Hyperthermia. 2001 Nov-Dec;17(6):465-82.

2001 -- Pubmed # 11597805 -- Hernando ML, Marks LB, Bentel GC, Zhou SM, Hollis D, Das SK, Fan M, Munley MT, Shafman TD, Anscher MS, Lind PA. Radiation-induced pulmonary toxicity: a dose-volume histogram analysis in 201 patients with lung cancer. Int J Radiat Oncol Biol Phys. 2001 Nov 1;51(3):650-9.

2001 -- Pubmed # 11429221 -- Kang SK, Chou RH, Dodge RK, Clough RW, Kang HL, Bowen MG, Steffey BA, Das SK, Zhou SM, Whitehurst AW, Buckley NJ, Kim JH, Joyner RE, Sarmina I, Montana GS, Ingram SS, Anscher MS. Acute urinary toxicity following transperineal prostate brachytherapy using a modified Quimby loading method. Int J Radiat Oncol Biol Phys. 2001 Jul 15;50(4):937-45.

1999 -- Pubmed # 10529914 -- Craciunescu OI, Das SK, Clegg ST. Dynamic contrast-enhanced MRI and fractal characteristics of percolation clusters in two-dimensional tumor blood perfusion. J Biomech Eng. 1999 Oct;121(5):480-6.

1999 -- Pubmed # 10076991 -- Das SK, Clegg ST, Samulski TV. Computational techniques for fast hyperthermia temperature optimization. Med Phys. 1999 Feb;26(2):319-28.

1999 -- Pubmed # 10458569 -- Das SK, Clegg ST, Samulski TV. Electromagnetic thermal therapy power optimization for multiple source applicators. Int J Hyperthermia. 1999 Jul-Aug;15(4):291-308.

1998 -- Das, S. K., Whiddon, C. S., Marks, L. B., A Quantitative Comparison of Fixed Conformal Beams vs. Arcs for Regular and Eccentrically Shaped Lesions, The Journal of Radiosurgery, Vol. 1, No. 3, 177-190, 1998.

1997 -- Pubmed # 9231691 -- Das SK, Marks LB. Selection of coplanar or noncoplanar beams using three-dimensional optimization based on maximum beam separation and minimized nontarget irradiation. Int J Radiat Oncol Biol Phys. 1997 Jun 1;38(3):643-55.

1996 -- Pubmed # 8676009 -- Clegg ST, Das SK, Fullar E, Anderson S, Blivin J, Oleson JR, Samulski TV. Hyperthermia treatment planning and temperature distribution reconstruction: a case study. Int J Hyperthermia. 1996 Jan-Feb;12(1):65-76.

1995 -- Pubmed # 7636327 -- Clegg ST, Das SK, Zhang Y, Macfall J, Fullar E, Samulski TV. Verification of a hyperthermia model method using MR thermometry. Int J Hyperthermia. 1995 May-Jun;11(3):409-24.

1995 -- Pubmed # 8586901 -- Das SK, Clegg ST, Anscher MS, Samulski TV. Simulation of electromagnetically induced hyperthermia: a finite element gridding method. Int J Hyperthermia. 1995 Nov-Dec;11(6):797-808.

1995 -- Marks, L. B., Sherouse, G. W., Das, S. K., Bentel, G. C., Spencer, D. P., Turner, D., "Conformal Radiation Therapy with Fixed Shaped Noncoplanar Radiation Beam Bouquets: A Possible Alternative to Radiosurgery", International Journal of Radiation Oncology Biology, Physics, Vol. 33, No. 5, pp. 1209-1219, 1995.

1994 -- Oleson, J. R., Samulski, T. V., Clegg, S. T., Das, S. K., Grant, W. J., "SAR Modeling and Measurements in Phantom and In Vivo of the Human Upper Extremity in a 2450 MHz Microwave Oven Field", Journal of Microwave Power and Electromagnetic Energy, Vol. 29, pp. 101-108, 1994.

1994 -- Samulski, T. V., Clegg, S. T., Das, S. K., MacFall, J., Prescott, D. M., ÒApplication of New Technology in HyperthermiaÓ, George Hahn Symposium, Stanford, CA, International Journal of Hyperthermia, Vol. 10, pp. 389-394, 1994.