function openWin(figure) {
if (figure == 1) {
var img = "figures/1a.jpg";
var text = "Figure 1a - Drawing depicting mouse with skin flap window chamber. ";
text += "Tumors are grown in the fascial plane covered by ";
text += "glass coverslips. These devices are very well ";
text += "tolerated by the mice and allow for serial observation of ";
text += "angiogenesis and blood flow over many days.";
var img2 = "figures/1b.jpg";
var text2 = "Figure 1b - Appearance of tumor as it grows in a skin fold window chamber. An ";
text2 += "extensive network of vessels that deliver nutrients to the tumor are ";
text2 += "seen on one side of the chamber (right hand panel). On the other ";
text2 += "side, the vascular network is much less well developed and this side ";
text2 += "frequently has insufficient oxygen and build up of waste products of ";
text2 += "metabolism (left hand panel).";
} else if (figure == 2) {
var img = "figures/2.jpg";
var text = "Figure 2 - Phosphorescence Lifetime Imaging of Tumor Oxygenation in ";
text += "skin flap window chamber model. ";
text += "The lower surface of the chamber has arteriolar supply ";
text += "and is better oxygenated. ";
text += "The upper surface (only 0.2mm from the bottom)has very little oxygen.";
} else if (figure == 3) {
var img = "figures/3.jpg";
var text = "Figure 3 - Artist\'s depiction of steps of Incipient Angiogenesis
"
text += "(A) Initial placement of cells into fascia
";
text += "(B) Vasodilation, increased tortuosity and polar movement of cells toward host vessels
";
text += "(C) Cuff formation of tumor cells around host vessel
";
text += "(D) Initial stages of new vessel formation";
} else if (figure == 4) {
var img = "figures/4a.jpg";
var text = "Figure 4a - Model for study of early tumor angiogenesis in dorsal skin flap of mice.
";
text += "Day 1 - Appearance of a few cells 24 hr post transplantation.
";
text += "Day 2 - Elongation and migration of tumor cell toward existing host vasculature (red arrow)."
text += "Day 3 - Further cell proliferation. Note that the existing host vasculature is more dilated and tortuous.
";
text += "Day 8 - First evidence for new vessel formation (pink arrows) in and surrounding the growing tumor mass which is estimated to have approximately 300 cells at this point.";
var img2 = "figures/4b.jpg";
var text2 = "Figure 4b - Polar Movement of tumor cells toward existing host vasculature.
";
text2 += "These figures come from a paper published by our group (Li, C., Shan, ";
text2 += "S., Huang, Q., Braun, R., Lanzen, J., Hu, K., Lin, P., and Dewhirst, ";
text2 += "M. Initial stages of tumor cell-induced angiogenesis: Evaluation via ";
text2 += "skin window chambers in rodents, J. Natl. Cancer Inst. 92: 143-147, ";
text2 += "2000).";
} else if (figure == 5) {
var img = "figures/5.gif";
var text = "Figure 5 - Effects of anticancer drug (doxorubicin) carrying liposomes, ";
text += "with heat treatment (42¡C / 108¡F) on tumor growth in a human tumor transplanted into nude mice.
";
text += "Each curve represents an individual tumor.Ê Upper left hand curve = Heat alone control
";
text += "Upper right hand curve = non-thermally sensitive liposome; Lower left hand curve = slow release thermally ";
text += "sensitive liposome (releases drug over 30 min); Lower right hand curve = new fast release thermally sensitive ";
text += "liposome (releases drug over 20sec).Ê The time needed for tumor growth was slower for all liposome groups, ";
text += "compared with the saline control.Ê The most striking effect, however, was seen with the fast release liposome, ";
text += "where 11/11 tumors regressed and did not recur up to 60 days post treatment.
";
text += "Data taken from: Needham, D., Anyarambhatla, G., Kong, G., and Dewhirst, M. W. A new temperature-sensitive ";
text += "liposome for use with mild hyperthermia: characterization and testing in a human tumor xenograft model ";
text += "[In Process Citation], Cancer Res. 60: 1197-201, 2000.";
}
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figWin.document.write("Figure " + figure + "![](" + img + ")
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if (figure == 1 || figure == 4) {
figWin.document.write("
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}
figWin.document.write("
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}