1.
Secomb TW, Hsu R, Ong ET, Gross JF, DEWHIRST
MW: Analysis of the effects of oxygen supply
and demand on hypoxic fraction in tumors. Acta Oncologica
34:313-316, 1995.
2. Meyer RE, Shan S, DeAngelo J, Dodge RK, Bonaventura J,
Ong ET, DEWHIRST
MW: Nitric oxide synthase inhibition irreversibly
decreases perfusion in the R3230Ac rat mammary adenocarcinoma.
British Journal of Cancer 71:1169-1174, 1995.
3.
Castellino SM, Friedman HS, Elion GB, Ong ET, Marcelli SL,
Page R, Bigner DD, DEWHIRST
MW: Flunarizine enhancement of melphalan activity
against drug-sensitive/resistant rhabdomyosarcoma. British
Journal of Cancer 71:1181-1187, 1995.
4. Brizel DM, Lin S, Johnson JL, Brooks J, DEWHIRST
MW, Piantadosi CA: The mechanisms by which hyperbaric
oxygen and carbogen improve tumor oxygenation. British Journal
of Cancer 72:1120, 1124, 1995.
5. Schuster JM, Zalutsky MR, Noska MA, Dodge R, Friedman HS,
Bigner DD, DEWHIRST
MW: Hyperthermic modulation of radiolabeled
antibody uptake in a human glioma xenograft and normal tissues.
International Journal of Hyperthermia 11:59-72, 1995.
6.
Prosnitz LR, DEWHIRST
MW: Progress toward a thermal dosimetry system
[editorial; comment]. International Journal Radiation Oncology
Biology Physics 33:963-964, 1995.
7.
Foltz RM, McLendon RE, Friedman HS, Dodge RK, Bigner DD, DEWHIRST
MW: A pial window model for the intracranial
study of human glioma microvascular function. Neurosurgery
36:976-985, 1995.
8.
Page RL, Lee J, Riviere JE, Dodge RK, Thrall DE, DEWHIRST
MW: Absence of whole body hyperthermia effect
on cisplatin distribution in spontaneous canine tumors. International
Journal Radiation Oncology Biology Physics 32:1097-1102, 1995.
9.
Brizel DM, Rosner GL, Prosnitz LR, DEWHIRST
MW: Patterns and variability of tumor oxygenation
in human soft tissue sarcomas, cervical carcinomas, and lymph
node metastases. International Journal Radiation Oncology
Biology Physics 32:1121-1125, 1995.
10.
Kimura H, Wu NZ, Dodge R, Spencer DP, Klitzman BM, McIntyre
TM, DEWHIRST
MW: Inhibition of radiation-induced up-regulation
of leukocyte adhesion to endothelial cells with the platelet
activating factor inhibitor, BN52021. International Journal
of Radiation Oncology Biology Physics 33:627-633, 1995.
11.
Minsley GE, DEWHIRST
MW, Tucker MR. Craniofacial implants in irradiated
bone: clinical and laboratory experiences. Proceedings of
the First International Congress on Maxillofacial Prosthetics,
Indian Wells, CA, April 27-30, 1994 (New York: Memorial Sloan-Kettering
Cancer Center, 1995),
pp. 297-304.
12.
DEWHIRST
MW., LaRue SM, and Gerweck L: Tumor physiology
and cell kinetics, Semin Vet Med Surg (Small Anim). 10: 148-57,
1995.
13.
Gaber MH, Wu NZ, Hong K, Huang SK, DEWHIRST
MW: Papahadjopoulos D: Thermosensitive liposomes:
Extravasation and release of contents in tumor microvascular
networks. International Journal Radiation Oncology Biology
Physics 36:1177-1187, 1996.
14.
Hauck ML, DEWHIRST
MW, Zalutsky MR: The effects of clinically relevant
hyperthermic temperatures on the kinetic binding parameters
of a monoclonal antibody. Nuclear Medicine and Biology 23:551-557,
1996.
15.
Raleigh JA, DEWHIRST
MW, Thrall DE: Measuring Tumor Hypoxia. Seminars
in Radiation Oncology 6:37-45, 1996.
16.
Lindberg RA, DEWHIRST
MW, Buckley BJ, Hughes CS, Whorton AR: Calcium-dependent
nitric oxide release in EA.hy926 endothelial but not R3230Ac
rat mammary adenocarcinoma cells. American Journal of Physiology
271 (Cell Physiology 40): C332-C337, 1996.
17.
Gulledge CJ, DEWHIRST
MW: Tumor oxygenation: A matter of supply and
demand. Anticancer Research 16:741-750, 1996.
18.
DEWHIRST
MW, Kimura H, Rehmus SWE, Braun RD, Papahadjopoulos
D, Hong K, Secomb TW: Microvascular studies on the origins
of perfusion-limited hypoxia. British Journal of Cancer 74:S241-S246,
1996.
19.
DEWHIRST
MW, Ong ET, Rosner GL, Rehmus SWE, Shan S, Braun
RD, Brizel DM, Secomb TW: Arteriolar oxygenation in tumor
and subcutaneous arterioles: Effects of inspired air oxygen
content. British Journal of Cancer 74:S247-S251, 1996.
20. Brizel DM, Scully SP, Harrelson JM, Layfield LJ, Bean
JM, Prosnitz LR, DEWHIRST
MW: Tumor oxygenation predicts for the likelihood
of distant metastases in human soft tissue sarcoma. Cancer
Research 56:941-943, 1996.
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the Top
21.
Rosner GL, Clegg ST, Prescott DM, DEWHIRST, MW: Estimation
of cell survival in tumors heated to nonuniform temperature
distributions. International Journal of Hyperthermia 12:223-239,
1996
22.
Thrall DE, Prescott DM, Samulski TV, Denman DL, Legorreta
RL, Rosner GL, Dodge RK, Page RL, Cline JM, Lee J, Evans SM,
Oleson JR, DEWHIRST
MW: Radiation plus local hyperthermia versus
radiation plus the combination of local and whole body hyperthermia
in canine sarcomas. International Journal Radiation Oncology
Biology Physics 34(5):1087-1096, 1996.
23.
Brizel DM, Scully SP, Harrelson JM, Layfield LJ, Dodge RK,
Charles HC, Samulski TV, Prosnitz LR, and DEWHIRST
MW. Radiation Therapy and Hyperthermia Improve
the Oxygenation of Human Soft Tissue Sarcomas. Cancer Research.
56:5347-5350. 1996.
24.
Kimura H, Braun RD, Ong ET, Hsu R, Secomb TW, Papahadjopoulos
D, Hong K, DEWHIRST
MW: Fluctuations in red cell flux in tumor microvessel
lead to transient hypoxia and reoxygenation in tumor parenchyma.
Cancer Research 56:5522-5528, 1996.
25.
Jones DN, McCowage G, Sostman HD, Brizel DM, Layfield L, Charles
HC, DEWHIRST
MW, Prescott DM, Friedman HS, Harrelson JM,
Scully SP, Coleman RE: Monitoring of neoadjuvant therapy response
of soft tissue and musculoskeletal sarcomas using F18-FDG
PET: initial evaluation. Journal of Nuclear Medicine 37:1438-1444,
1996.
26.
Hettasch JM, Bandarenko N, Lai T-S, Marks JR, Haroon Z, Peters
K, DEWHIRST
MW, Iglehart, JD, Greenberg CS. Tissue transgluminase
expression in human breast cancer. Laboratory Investigator
Laboratory Investigation 75:637-645, 1996.
27.
Hauck ML, Price GS, Ogilvie GK, Johnson J, Gillette EL, Thrall
DE, DEWHIRST
MW., and Page RL: Phase I evaluation of mitoxantrone
alone and combined with whole body hyperthermia in dogs with
lymphoma, Int J Hyperthermia. 12: 309-20, 1996.
28.
Zalutsky MR, Schuster JM, Garg PK, Archer GE Jr., DEWHIRST
MW, and Bigner DD: Two approaches for enhancing
radioimmunotherapy: alpha emitters and hyperthermia, Recent
Results Cancer Res. 141: 101-22, 1996.
29.
Raleigh JA, DEWHIRST
MW, and Thrall DE: Measuring Tumor Hypoxia,
Semin Radiat Oncol. 6: 37-45, 1996.
30.
Shan SQ, Rosner GL, Braun RD, Hahn J, Pearce C, DEWHIRST
MW: Effects of diethylamine/nitric oxide on
blood perfusion in the R3230Ac mammary carcinoma. British
Journal of Cancer 76:429-437, 1997.
31.
Hauck ML. DEWHIRST
MW, Bigner DD, Zalutsky ML: Local hyperthermia
improves uptake of a chimeric monoclonal antibody in a subcutaneous
xenograft model. Cl Cancer Research 3:63-70, 1997.
32.
Anscher MS, Samulski TV, Rosner G, Dodge R, Prosnitz L, DEWHIRST
MW: Combined external beam irradiation and external
regional hyperthermia for locally advanced adenocarcinoma
of the prostate. International Journal of Radiation Oncology
Biology and Physics 37:1059-1065, 1997.
33. Braun RD, DEWHIRST
MW, Hatchell DL. Quantification of erythrocyte
flow in the choroid. Am.J. Physiol. 272:H1444-H1453, 1997.
34. Wu NZ, Braun RD, Gaber MH, Lin GM, Ong ET, Shan S, Papahadjopoulos
D, DEWHIRST
MW. Simultaneous measurment of liposome extravasation
and content release in tumors. Microcirculation 4:83-101,
1997.
35. Hahn JS, Braun RD, DEWHIRST
MW, Shan S, Snyder SA, Taub JM, Ong ET, Rosner
GL, Dodge RK, Bonaventura J, Bonaventura C, DeAngelo J, Meyer
RE: Stroma-free human hemoglobin A decreases R3230Ac rat mammary
adenocarcinoma blood flow and oxygen partial pressure. Radiation
Research 147:185-194, 1997.
36.
Hauck ML, Coffin DO, Dodge RK, DEWHIRST
MW, Mitchell JB, Zalutsky MR. A local hyperthermia
treatment which enhances antibody uptake in a glioma xenograft
model does not affect tumour interstitial fluid pressure.
International Journal of Hyperthermia 13:307-316, 1997.
37.
Brizel DM, Prosnitz LR, Sibley GS, Scher RL, Rosner GL, DEWHIRST
MW. Tumor hypoxia adversely affects to prognosis
of carcinoma of the head and neck. International Journal Radiation
Oncology Biology Physics 38:285-289, 1997.
38.
Wong AL, Haroon Z, Werner S, DEWHIRST
W, Greenberg CS, Peters K. Tie2 expression and
phosphyorylation of in angiogenic and quiescent adult tissues.
Circulation Research 81:567-574,1997.
39.
Brizel DM, Hage WD, Dodge RK, Munley MT, Piantadosi CA, DEWHIRST
MW. Hyperbaric oxygen improves tumor radiation
response significantly more than carbogen/nicotinamide. Radiation
Research 147:715-720, 1997.
40.
Nozue M, Lee I, Yuan F, Teicher BA, Brizel DM, DEWHIRST
MW, Milross CG, Milas L, Song CW, Thomas CD,
Guichard M, Evans SM, Koch CJ, Lord EM, Jain RK, Suit HD:
Interlaboratory variation in oxygen tension measurement by
Eppendorf "histograph" and comparison with hypoxic marker.
Journal of Surgical Oncology 66:30-38, 1997.
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the Top
41.
Wong AL, Haroon ZA, Werner S, DEWHIRST
MW, Greenberg CS, and Peters KG: Tie2 expression
and phosphorylation in angiogenic and quiescent adult tissues,
Circ Res. 81: 567-74, 1997.
42.
Lin P, Polverine P, DEWHIRST
MW, Shan S, Rao PS, Peters K. Inhibition of
tumor angiogenesis using a soluble receptor establishes a
role for Tie2 in pathologic vascular growth. J Clin Invest
100:2072-2078, 1997.
43.
Bryce TJ, DEWHIRST
MW, Floyd CE, Hars V, Brizel DM. Artificial
neural network model of survival in patients treated with
irradiation with irradiation with and without concurrent chemotherapy
for advanced carcinoma of the head and neck. International
Journal Radiation Oncology Biology Physics 41:339-345, 1998.
44.
Lin P, Sankar S, Shan S, DEWHIRST
MW, Polverini P, Quinn T, Peters K. Inhibition
of tumor growth by targeting tumor endothelium using a soluble
vascular endothelial growth factor receptor. Cell Growth and
Differentiation 9:49-58, 1998.
45.
Acker JC, Marks LB, Spencer DP, Yang W, Avery MA, Dodge RK,
Rosner GL, DEWHIRST
MW. Serial in vivo observations of cerebral
vasculature after treatment with a large single fraction of
radiation. Radiation Research 149:350-359, 1998.
46.
Wink DA, Vodovotz Y, Laval J, Laval F, DEWHIRST
MW, Mitchell JB. The multifaceted roles of NO
in cancer. Carcinogenesis 19(5):711-2, 1998.
47.
Sneed PK, DEWHIRST
MW, Samulski T, Blivin J, and Prosnitz LR: Should
interstitial thermometry be used for deep hyperthermia? [editorial;
comment], Int J Radiat Oncol Biol Phys. 40: 1015-7, 1998.
48. DEWHIRST
MW and Mitchell JB: Introduction, Semin Radiat
Oncol. 8: 141-2, 1998.
49.
DEWHIRST
MW: Concepts of oxygen transport at the microcirculatory
level, Semin Radiat Oncol. 8: 143-50, 1998.
50.
DEWHIRST
MW and Corry PM: Further justification for development
of non-invasive thermometry [editorial; comment], International
Journal of Hyperthermia. 14: 255, 1998.
51. Wilson DF, Evans SM, Jenkins WT, Vinogradov SA, Ong E,
and DEWHIRST
MW: Oxygen distributions within R3230Ac tumors
growing in dorsal flap window chambers in rats, Adv Exp Med
Biol. 454: 603-9, 1998.
52.
Secomb TW, Hsu R, Braun RD, Ross JR, Gross JF, and DEWHIRST
MW: Theoretical simulation of oxygen transport
to tumors by three-dimensional networks of microvessels, Adv
Exp Med Biol. 454: 629-34, 1998.
53.
Huang Q, Shan S, Braun RD, Lanzen J, Anyrhambatla G, Kong
G, Borelli M, Corry P, DEWHIRST
MW, and Li CY: Noninvasive visualization of
tumors in rodent dorsal skin window chambers, Nat Biotechnol.
17: 1033-5, 1999.
54.
Larue SM, Fox MH, Ogilvie GK, Page RL, Getzy DM, Thrall DE,
Johnson JL, DEWHIRST
MW and Gillette EL: Tumour cell kinetics as
predictors of response in canine lymphoma treated with chemotherapy
alone or combined with whole body hyperthermia, Int J Hyperthermia.
15: 475-86, 1999.
55.
Haroon ZA, Lai TS, Hettasch JM, Lindberg RA, DEWHIRST
MW, and Greenberg CS: Tissue transglutaminase
is expressed as a host response to tumor invasion and inhibits
tumor growth, Lab Invest. 79: 1679-86, 1999.
56.
Lin P, Buxton JA, Acheson A, Redziewjewski C, Maisonpierre
PC, Yancopoulos GD, Channon KM,DEWHIRST
MW, George SE, Peters KG. Antiangiogenic gene
therapy targetting the endothelium-specific receptor tyrosine
kinase Tie2. PNAS 95:8829-8834, 1998.
57.
DEWHIRST
MW, Ong ET, Braun RD, Smith B et al. Quantification
of longitudinal tissue p02 gradients in window chamber tumors:
Impact on tumor hypoxia. British Journal of Cancer 79:1717-1722,
1999.
58.
Biaglow JE, Manevich Y, Leeper D, Chance B, DEWHIRST
MW, Jenkins WT, Tuttle SW, Wroblewski K, Glickson
JD, Stevens C, Evans SM. MIBG inhibits respiration: potential
for radio-and hyperthermia sensitization. International Journal
of Radiation Oncology, Biology, Physics 42:871-876, 1998.
59.
DEWHIRST
MW, Braun RD, Lanzen JL. Temporal changes in
pO2 of R3230Ac tumors in fischer-344 rats. International Journal
of Radiation Oncology, Biology, Physics 42:723-726, 1998.
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the Top
60.
Lanzen JL, Braun RD, Ong AL, DEWHIRST
MW. Variability in blood flow and pO2 in tumors
in response to carbogen breathing. International Journal of
Radiation Oncology, Biology, Physics 42:855-859, 1998.
61.
Dunn TJ, Braun RD, Rhemus WE, Rosner GL, Secomb TW, Tozer
GM, Chaplin DJ, DEWHIRST
MW. The effects of hyperoxic and hypercarbic
gases on tumour blood flow. British Journal of Cancer 80:117-126,
1999.
62. Krol A., Maresca J, DEWHIRST
MW, Yuan F. Available volume fraction of macromolecules
in a fibrosarcoma: Implication for drug delivery. Cancer Research
59:4136-4141, 1999.
63.
Thrall DE, LaRue SM, Powers BE, Page RL, Johnson J, George
SL, Kornegay JN, McEntee MC, Case BC, DEWHIRST
MW, Gillette EL. Use of whole body hyperthermia
as a method to heat inaccessible tumors uniformly: A phase
III trial in canine brain masses. Int Journal of Hyperthermia
15:383-398, 1999.
64.
Kong G and DEWHIRST
MW. Hyperthermia and liposomes: a review. Int.
Journal of Hyperthermia. 15:345-370, 1999.
65.
Prosnitz LR, Maguire P, Anderson JM, Scully SP, Harrelson
JM, Jones EL, DEWHIRST
MW, Samulski TV, Powers BE, Rosner GL, Dodge
RK, Layfield L, Clough R, Brizel DM. The treatment of high
grade soft tissue sarcomas with preoperative thermoradiotherapy.
. International Journal of Radiation Oncology, Biology, Physics
45:941-949, 1999.
66.
Braun R, Lanzen JL, DEWHIRST
MW. Fourier analysis of fluctuations of oxygen
tension and blood flow in R3230Ac tumors and muscle in rats.
American Physiology Society 277:H551-H568, 1999.
67.
Haroon ZA, Hettasch JM, Lai TS, DEWHIRST
MW, Greenberg CS. Tissue transglutaminase is
expressed, active, and directly involved in rat dermal wound
healing and angiogenesis. FASEB 13:1787-1795, 1999.
68.
Brizel DM, Dodge RK, Clough RW, DEWHIRST
MW. Oxygenation of Head and Neck Cancer: Changes
During Radiotherapy and Impact on Treatment Outcome. The Green
Journal 53 (2): 113-117, 1999.
69.
Craciunescu O, Das SK, DEWHIRST
MW. Three-dimensional microvascular networks
fractal structure: potential for tissue characterization.
ASME Proceedings, 1999.
70.
Vujaskovic Z, Poulson JM, Gaskin AA, Thrall DE, Page RL, Charles
HC, MacFall JR, Brizel DM, Meyer RE, Prescott DM, Samulski
TV, DEWHIRST
MW. Temperature dependent changes in physiologic
parameters of spontaneous canine soft tissue sarcomas after
combined radiotherapy and hyperthermia treatment. International
Journal of Radiation Oncology Biology Physics 46:179-185,
1999.
71.
Huang Q, Shan S, Braun RD, Lanzen J, Anyrhambatla G, Kong
G, Borelli M, Corry P, DEWHIRST
MW, and Li C-Y: GFP based non-invasive, in vivo
monitoring of gene expression. Nature Biotechnology, vol 17,
1999,
pp1033-1035.
72.
Secomb TW, Hsu R, Braun RD, DEWHIRST
MW. Analysis of Oxygen transport to tumors:
causes of heterogenous tissue oxygenation. 1999 Buioengineering
Conference, Big Sky Montana, June 16-20, 1999.
BED Vol. 42, pp 487-488, 1999.
73.
Li CY, Huang Q, Braun RD, Lanzen J, Turnage J, DEWHIRST
MW: (2000)
Initial stages of tumor cells-induced angiogenesis:evaluation
via skin window chambers in rodent models Journal of the National
Cancer Institute, vol 92, pp143-127.
74.
Huang Q, Hu K, Lohr F, Zhang L, Braun R, Lanzen J, Little
JB, DEWHIRST
MW, and Li C-Y: Heat-induced Gene Expression
as a Novel Targeted Cancer Gene Therapy Strategy Cancer Research,
In Press (July 1, 2000).
75.
Lohr F, Hu K, Haroon Z, Samulski TV, Huang Q, Beaty J, DEWHIRST
MW, and Li, C-Y: Combination treatment of murine
tumors by adenovirus mediated local B7/IL12 immunotherapy
and radiotherapy. Submitted to Molecular Therapy
76.
DEWHIRST
MW, Tozer G, Wilson J, Rosner G, Lanzen J, Kaz
A, Snyder S, Stamier, J. Modulation of Tumor Blood Flow by
Nitric Oxide, [in] Radiation Research Volume 2; Congress Proceedings,
Moriarity M, Mothersill C, Seymour C, Eddington M, Ward JF,
Fry RJM (eds), Allen Press, Lawrence, KA, pp 610 - 613, 2000.
77. DEWHIRST
MW, Kong G, Needham D. Use of Hyperthermia to
Augment Liposomal Drug Delivery to Tumours, [in] Radiation
Research Volume 2; Congress Proceedings, Moriarity M, Mothersill
C, Seymour C, Eddington M, Ward JF, Fry RJM (eds), Allen Press,
Lawrence, KA, pp 853 - 856, 2000.
78.
Blackwell K, Haroon Z, Broadwater G, Berry D, Harris L, Inglehart
JD, DEWHIRST
MW, Greenberg C. Plasma D-Dimer Levels in Operable
Breast Cancer Patients Correlate With Clinical Stage and Auxillary
Lymph Node Status, Journal of Clinical Oncology, Vol 18, No.
3 (February), pp 600-608, 2000.
79. Haroon ZA, Raleigh JA, Greenberg CS, and DEWHIRST
MW: Early wound healing exhibits cytokine surge
without evidence of hypoxia, Ann Surg. 231: 137-47, 2000.
80.
Kong G, Braun RD, DEWHIRST
MW. Hyperthermia enables tumor-specific nanoparticle
delivery: effect of particle size. Cancer Research , (in Press
2000).
81.
Haroon ZA, Raleigh JA, Greenberg CS, DEWHIRST
MW. Early wound healing exhibits cytokine surge
without evidence of hypoxia. Annals of Surgery 231: 137-147,
2000.
82. Thrall DE, Rosner GL, Azuma C, LaRue SM, Case BC, Samulski
T, DEWHIRST
MW. Using units of CEM 43oC T90, local hyperthermia
thermal dose can be delivered as prescribed. International
Journal of Hyperthermia (In Press, 1999).
83.
Vujaskovic Z, Poulson JM, Charles HC, Prescott DM, Page RL,
Thrall DE, DEWHIRST
MW. The Relationship between intracellular and
extracellular pH in spontaneous canine tumors. Clinical Cancer
Research 6: 2501-2505, 2000.
84.
Minning DM, Gow AJ, Bonaventura J, Braun R,
DEWHIRST
M, Goldberg DE, Stamler JS. Ascaris haemoglobin
is a nitric oxide-activated 'deoxygenase.' Nature 401:497-502,
1999.
85.
Biaglow JE, Lee I, Donahue J, Held K, Mieyal J, DEWHIRST M,
Tuttle S. Glutathione depletion or radiation treatment alters
respiration and induces apoptosis in R3230Ac mammary carcinoma.
Proceedings of the 1999
ISOTT conference, Dartmouth (in press, 1999).
86.
Lee I, Glickson JD, DEWHIRST
MW, Leeper DB, Burd R, Poptani H, Nada L, McKenna
G, Biaglow JE. Effect of mild hyperglycemia +/- meta-iodo-benzylguanidine
on the radiation response of R3230 AC tumors. Proceedings
of the 1999
ISOTT conference, Dartmouth (in press, 1999).
87.
Matteucci ML, Anyarambhatla G, Rosner G, Azuma C, Fisher PE,
DEWHIRST
MW, Needham D, Thrall DE. Hyperthermia increases
extravasation of technetium-99m labeled liposomes in feline
sarcomas. Clinical Cancer Research (in press, 2000).
88. Adams DJ, DEWHIRST
MW, Flowers JL, Gamcsik MP, Colvin OM, Manikumar
G, Wani MC, Wall ME. Camptothecin analogues with selective
antitumor activity at acidic pH. Cancer Chemotherapy and Pharmacology
(in press, 2000).
89. Prescott DM, Charles HC, Poulson JM, Page RL, Thrall DE,
Vujaskovic Z and DEWHIRST
MW. The relationship between intracellular and
extracellular pH in spontaneous canine tumors. Clinical Cancer
Research vol 6., ppp2501-2505, 2000.
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